Genomic Characterization of Salmonella Isangi: A Global Perspective of a Rare Serovar

Salmonella Isangi is an infrequent serovar that has recently been reported in several countries due to nosocomial infections. A considerable number of reports indicate multidrug resistance, especially cephalosporins, which could potentially pose a risk public health worldwide. Genomic analysis excellent tool for monitoring the emergence microorganisms and related factors. In this context, aim study was carry out genomic isolated from poultry Brazil, compare it with available genomes Pathogen Detection database Sequence Read Archive. total 142 11 different were investigated. broad distribution extended-spectrum beta-lactamase (ESBL) genes identified examined (blaCTX-M-15, blaCTX-M-2, blaDHA-1, blaNDM-1, blaOXA-10, blaOXA-1, blaOXA-48, blaSCO-1, blaSHV-5, blaTEM-131, blaTEM-1B), primarily South Africa. Resistome revealed predicted resistance aminoglycoside, sulfonamide, macrolide, tetracycline, trimethoprim, phenicol, chloramphenicol, quaternary ammonium. Additionally, PMQR (plasmid-mediated quinolone resistance) qnr19, qnrB1, qnrS1 identified, along point mutations gyrAD87N, gyrAS83F, gyrBS464F, confer ciprofloxacin nalidixic acid. With regard plasmids, we 17 incompatibility groups, including IncC, Col(pHAD28), IncHI2, IncHI2A, IncM2, ColpVC, Col(Ye4449), Col156, IncR, IncI1(Alpha), IncFIB (pTU3), Col(B5512), IncQ1, IncL, IncN, IncFIB(pHCM2), (pN55391). Phylogenetic five clusters grouped by sequence type antimicrobial gene distribution. The highlights need rare serovars may become emergent resistance.